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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MYOC All Species: 18.18
Human Site: T462 Identified Species: 44.44
UniProt: Q99972 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99972 NP_000252.1 504 56972 T462 T G T G I S K T L T I P F K N
Chimpanzee Pan troglodytes XP_513995 490 55353 T448 T G T G I S K T L T I P F K N
Rhesus Macaque Macaca mulatta XP_001099905 491 55540 T449 T G T G I S K T L T I P F K N
Dog Lupus familis XP_537805 678 75531 I631 N A S T Y E Y I D I P F Q N K
Cat Felis silvestris
Mouse Mus musculus O70624 490 55295 T448 T K T G T S K T L T I P F T N
Rat Rattus norvegicus Q9R1J4 502 56424 T460 T N T G I S K T L T I P F K N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515085 485 53353 A445 T N S S E A L A V P F K N Q Y
Chicken Gallus gallus Q9IAK4 485 55511 Y446 D I P F Q N K Y S H I S M L D
Frog Xenopus laevis B5MFE9 392 45091 K353 V P I V Y F P K R Y G S H S S
Zebra Danio Brachydanio rerio Q29RB4 390 44487 P351 E A P H V Y F P K R Y G T H S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96 94.2 25.8 N.A. 79.5 80.9 N.A. 58.5 29.1 25 23.2 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 96.6 96.2 42 N.A. 87.5 89 N.A. 73.2 49.2 42.6 44.4 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 0 N.A. 80 93.3 N.A. 6.6 13.3 0 0 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 6.6 N.A. 80 93.3 N.A. 33.3 26.6 6.6 13.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 20 0 0 0 10 0 10 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 0 0 0 0 0 0 0 10 0 0 0 0 0 10 % D
% Glu: 10 0 0 0 10 10 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 10 0 10 10 0 0 0 10 10 50 0 0 % F
% Gly: 0 30 0 50 0 0 0 0 0 0 10 10 0 0 0 % G
% His: 0 0 0 10 0 0 0 0 0 10 0 0 10 10 0 % H
% Ile: 0 10 10 0 40 0 0 10 0 10 60 0 0 0 0 % I
% Lys: 0 10 0 0 0 0 60 10 10 0 0 10 0 40 10 % K
% Leu: 0 0 0 0 0 0 10 0 50 0 0 0 0 10 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % M
% Asn: 10 20 0 0 0 10 0 0 0 0 0 0 10 10 50 % N
% Pro: 0 10 20 0 0 0 10 10 0 10 10 50 0 0 0 % P
% Gln: 0 0 0 0 10 0 0 0 0 0 0 0 10 10 0 % Q
% Arg: 0 0 0 0 0 0 0 0 10 10 0 0 0 0 0 % R
% Ser: 0 0 20 10 0 50 0 0 10 0 0 20 0 10 20 % S
% Thr: 60 0 50 10 10 0 0 50 0 50 0 0 10 10 0 % T
% Val: 10 0 0 10 10 0 0 0 10 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 20 10 10 10 0 10 10 0 0 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _